TITRALGAN Tablets for pain, 20 pcs

Instructions for use for TITRALGAN Tablets for pain, 20 pcs

Detailed instructions for TITRALGAN Tablets for pain, 20 pcs

Field of use

• The preparation is a combination of acetylsalicylic acid and paracetamol, two active ingredients from the group of pain inhibitors and fever (analgesic/antipyreticity), and caffeine.
• Field of use
  • For adults and adolescents from the age of 12 (from 43 kg) in acute light to moderately severe pain

Active ingredients / ingredients / ingredients

250 mg acetylsalicylic acid
50 mg caffeine
200 mg paracetamol
Corn starch auxiliary substance (+)
Stearic acid auxiliary material (+)
Talcum auxiliary material (+)
WheatStrength Hedge substance (+)

Contradictions

• The medicine must not be taken
  • if you are hypersensitive to acetylsalicylic acid, paracetamol, caffeine, wheat strength or one of the other components of the preparation
  • if in the past you have reacted with asthma attacks or in other ways
  • if you earlier in connection with an application of non-steroidal inflammatory inhibitors (NSAID) gastrointestinal bleeding or a breakthrough (perforation)
  • if you suffer from gastrointestinal ulcers (peptic ulcers) or bleeding
  • if you have repeatedly suffered from gastrointestinal/duodenum ulcers (peptic ulcers) or bleeding (at least 2 different episodes of proven ulcers or bleeding)
  • with pathologically increased bleeding tendency
  • if you suffer from a serious impairment of the liver or kidney function
  • in the case of severe heart muscle weakness (heart failure)
  • if you take 15 mg or more methotrexate per week at the same time
  • in the last 3 months of pregnancy
  • of children and adolescents under the age of 12 (under 43 kg)

dosage

• Always take the medicine exactly according to the instruction. Please ask your doctor, dentist or pharmacist if you are not quite sure.
• Dosage
  • Unless otherwise prescribed by the doctor, the dosage is based on the information in the following table.
  • The respective dosage interval depends on the symptoms and the maximum total daily dose.
  • The maximum dose per day (24 hours) must never be exceeded, and the time interval between two applications must be at least 6 hours. The maximum dose of 6 tablets a day should not be exceeded.
  • From 43 kg of young people from 12 years and adults
    • Single dose in number of tablets: 1 - 2 tablets (corresponding to 250 - 500 mg acetylsalicylic acid, 200 - 400 mg paracetamol and 50 - 100 mg caffeine)
    • Max. Daily dose (24 hours) in number of tablets: up to 6 tablets (corresponding to 1500 mg acetylsalicylic acid, 1200 mg paracetamol and 300 mg caffeine)
• Special patient groups
  • Patients with light or moderately serious disorders of liver or kidney function
    • In these patients and in patients with Gilbert syndrome, the dose must be reduced or the dose interval is extended.
  • older patients
    • Due to the increased risk of side effects, these patients should begin with the lowest dosage and be monitored by a doctor.

 

• Duration of the application
  • Do not take the preparation without a medical or dental advice for more than 3 days.
  • Please speak to your doctor, dentist or pharmacist if you have the impression that the effect of the drug is too strong or too weak.

 

• If you have taken a larger amount than you should
  • Dizziness and ear blades, especially in children and older patients, can be signs of serious poisoning by acetylsalicylic acid.
  • With an overdose of paracetamol, complaints generally occur within 24 hours that include nausea, vomiting, loss of appetite, pallor and abdominal pain. There can also be severe liver damage.
  • Symptoms of poisoning through caffeine (central nervous symptoms, cardiovascular reactions up to damage to the heart muscle) can also occur when large quantities are taken in a short time.
  • If you suspect an overdose with the medicine, please notify a doctor immediately.
  • According to the severity of overdose/poisoning, this can decide on the measures necessary.

 

• If you have forgotten the intake
  • Do not take the double dose if you have forgotten the prior intake.

 

• If you have any further questions about the application of the drug, ask your doctor, dentist or pharmacist.

Taking

• Take the tablets unscrewed with sufficient liquid (e.g. a glass of water).
• Do not take on an empty stomach.

Patient information

• Particular caution when taking the drug is required
  • Side effects can be reduced by using the lowest effective dose via the shortest period required for symptom control.
  • In order to prevent the risk of overdose with paracetamol, it should be ensured that other medicines that are used at the same time do not contain any paracetamol.
  • You should only take the preparation with special caution and under medical control
    • if you are hypersensitive to other inflammatory inhibitors/anti -rheumatics (certain remedies for rheumatism or inflammation) or other allergy -causing substances
    • if you suffer from allergies (e.g. with skin reactions, itching, nettle fever) or asthma, hay fever, nasal mucosal swelling (nasal polyps) or chronic respiratory diseases
    • with simultaneous treatment with anti -blood clotting medicines
    • if you have already suffered from a gastrointestinal/duodenum ulceration (peptic ulceration) or a bleeding
    • if you suffer from a limited liver or kidney function due to diseases of the kidney or liver (liver inflammation, Gilbert syndrome)
    • if you are chronically alcoholic
    • if you suffer from high blood pressure and/or heart performance weakness (heart failure). Talk to your doctor or pharmacist about it before the start of treatment.
    • before operations (even with smaller interventions such as pulling a tooth): there may be increased tendency to bleed.
      • Please inform your doctor or dentist beforehand if you have taken the medicine.
    • if you tend to be less uric acid output: By taking the preparation, a gout attack can be triggered.
  • Caffeine should only be taken in low doses (approx. 100 mg, corresponds to two tablets of the preparation) or under medical control:
    • in the case of cardiac arrhythmias, such as sinus-untachycardia/extrasystoles (risk of reinforcement)
    • in the event of overactive thyroid (risk of caffeine side effects)
    • in the case of pathological anxiety (risk of reinforcement)
  • Do not take the drug without medical or dental advice for more than 3 days or in higher doses.
  • The preparation belongs to a group of drugs that can affect the fertility of women. This effect is reversible after stopping the drug (reversible).
• Unwanted effects on the gastrointestinal tract
  • A simultaneous application of the drug with other non-steroidal inflammatory inhibitors (NSAID), including so-called COX-2 inhibitors (cyclooxygenase-2 inhibitors), should be avoided.
  • The gastrointestinal tract, ulcers and breakthroughs (perforations), also with a fatal outcome, were reported during treatment with all non-steroidal inflammatory inhibitors (NSAID). They occurred with or without prior warning symptoms or serious events in the gastrointestinal tract in the prehistory at any time of therapy.
  • The risk of this is increased with increasing NSAR dose in patients with ulcers in the history, especially with the complications bleeding or breakthrough, and in older patients. These patients should begin treatment with the lowest available dose. Combination therapy with gastric mucosal-protecting medicines (e.g. misoprostol or proton pump inhibitor) should be considered here. This is also recommended for patients who take other medicines who increase the risk of a disease of the gastrointestinal tract.
  • If you have a history of side effects on the gastrointestinal tract, especially at older age, you should report any unusual symptoms in the abdomen (especially gastrointestinal bleeding), especially at the beginning of the therapy.
  • Caution is advisable if you get medicines that can increase the risk of ulcers or bleeding, such as: B. Oral corticosteroids, anti-blood clotting medication, such as warfarin, selective serotonin reuptake inhibitors that are used, among other things, to treat depressive moods, or thrombocyte aggregation inhibitors, such as acetylsalicylic acid.
  • If you have gastrointestinal bleeding or ulcers during treatment with the preparation, the treatment must be stopped immediately and contacted with a doctor.
  • Non-steroidal inflammatory inhibitors (NSAID) should be used in patients with a gastrointestinal disease in the history (ulcerative colitis, Crohn's disease) because their condition can deteriorate.
• Unwanted effects on the cardiovascular system
  • Medicines such as the preparation may be associated with a slightly increased risk of heart attacks ("heart attack") or strokes. These risks increase in higher doses and longer treatment. Do not exceed the recommended dose or treatment duration (maximum 3 days)!
  • If you have heart problems or a previous stroke or think that you could have a risk to these diseases (e.g. if you have high blood pressure, diabetes or high cholesterol or are smokers), you should be with your doctor or Pharmacists speak.
• Unwanted skin reactions
  • Under the therapy with non-steroidal inflammatory inhibitors (NSAID), very rarely about serious skin reactions with redness and bladder formation, some with a fatal outcome (exfediative dermatitis, Stevens-Johnson syndrome and toxic epidermal necolysis/lyell syndrome). The highest risk of such reactions seems to exist at the beginning of therapy, since these reactions occurred in the majority of cases in the first month of treatment. At the first sign of rashes, mucous membrane defects or other signs of a hypersensitivity reaction, the drug must be discontinued and a doctor must be consulted immediately.
• Other information
  • If painkillers are used for a long time, headaches can occur, which may not be treated by increased doses of the drug. Ask your doctor for advice if you often suffer from headache despite taking the preparation!
  • When stopping abruptly, headaches and fatigue, muscle pain, nervousness and vegetative symptoms can occur after a long -dosed, non -determined use of painkillers. This deduction symptoms sound within a fewer Days off. Until then, painkillers will be reinforced and re -taking it again should take place without medical advice.
  • The habitual intake of pain relievers, especially when combining several pain relieving active ingredients, can lead to permanent kidney damage with the risk of kidney failure (analgesics-nephropathy).
  • The more frequent intake should also be avoided in diabetes mellitus (diabetes), alcoholism, rheumatural therapy, dehydration (heavy drying out of the body e.g. after diarrhea, high outside temperatures, excessive physical stress with strong sweating), chronically too low blood pressure, serious injuries.
  • Due to the fever -lowering effect, an improvement in the disease can be faked. If necessary, medical advice must be obtained.
• Children and adolescents
  • The medicine must not be used in children and adolescents under the age of 12 (under 43 kg).
  • In children and adolescents over the age of 12, the preparation should only be applied to medical instructions with feverish illnesses and only if other measures do not work. If these diseases occur with long-lasting vomiting, this can be a sign of Reye syndrome, a very rare, but possibly life-threatening illness, which requires absolutely immediate medical treatment.
• Older people
  • In older patients, side effects occur more frequently after using non-steroidal inflammatory inhibitors (NSAID), in particular bleeding and breakthroughs in the stomach and intestinal area, which may be life-threatening. Therefore, particularly careful medical monitoring is required in older patients.

 

• Wateriness and operating machines
  • The medicine has no influence on the traffic and operating machines. Nevertheless, caution is always required after taking a pain reliever.

Pregnancy

• Ask your doctor or pharmacist for advice before using all medicines.
• Pregnancy
  • If pregnancy is determined during the application of the drug, the doctor must be notified.
  • The preparation should not be taken due to the active ingredients acetylsalicylic acid and caffeine during pregnancy, since pregnancy and/or the development of the unborn child can be affected. You should therefore only use the medicine in the first and second thirds of pregnancy after consultation with your doctor. In the last third of pregnancy, the medicine must not be used due to an increased risk of complications for mother and child.
• Breastfeeding
  • The active ingredients pass into breast milk. Since adverse consequences from paracetamol and acetylsalicylic acid for the infant have not yet become known, an interruption of breastfeeding is generally not necessary if the recommended dose is used. The condition and behavior of the infant can be affected by caffeine recorded with breast milk.
  • If higher doses are used for longer or taking higher doses.
• Fertility
  • The preparation belongs to a group of drugs that can affect the fertility of women. This effect is reversible after stopping the drug (reversible).

Hints

Do not apply longer for pain or fever without medical advice than specified in the package insert!

Miscellaneous

- The habitual taking of painkillers is dangerous. It can lead to irreparable damage to health. In general, the long -term taking of painkillers, especially when combining several pain relieved Active ingredients, lead to permanent kidney damage with the risk of kidney failure (analgesic nephropathy).
- The long -term use of the combination of the active substance can lead to an increased risk of disease for damage damage caused by pain relievers if the kidney damage or genetic assessment is pre -existing.
- In the case of long -dosed, non -determined use of pain relievers, headaches and tiredness, muscle pain, nervousness and vegetative symptoms can occur. This sounds within a few days. Until then, painkillers will be reinforced and re -taking it again should take place without medical advice.
- When taking surgical interventions, the doctor/dentist must be questioned or informed.
- If the black chair (TEERSUFL) occurs, the doctor must be notified immediately.

- If the recommended dosage is exceeded, the liver values (transaminases) can increase. Therefore, regular control of the transaminases, especially in children, is required.

Manufacturer:  BERLIN-CHEMIE AG, Glienicker Weg 125, 12489 Berlin