MAGNESIUM VERLA I.V. 50% Infus.-Lsg., 10x5 pcs

Instructions for use for MAGNESIUM VERLA I.V. 50% Infus.-Lsg., 10x5 pcs

Detailed instructions for MAGNESIUM VERLA I.V. 50% Infus.-Lsg., 10x5 pcs

Field of use

• The medicine is a mineral preparation.
• For pre -declampsia, eclampsia, premature birth efforts, severe magnesium deficiency (normal values of magnesium in serum 0.8 - 1.1 mmol/l).

Active ingredients / ingredients / ingredients

4930 mg magnesium sulfate 7 water
20 mmol magnesium ion
486.1 mg magnesium ion
20 mmol sulfate ion
1921.35 mg sulfate ion
Water, for injection purposes auxiliary material (+)

Contradictions

• The medicine must not be used,
  • if you are allergic to magnesium sulfate or one of the other components of this medicine.
  • in the case of pronounced bradycardia (slow heartedness),
  • at Myasthenia Gravis (muscle weakness)
  • in the case of AV block (interruption of the stimulus system in the heart)
  • in the event of a tendency to infect stones (calcium-magnesium-collection phosphate stones).

dosage

• Always apply the medicine as described or exactly according to your doctor or pharmacist. Ask your doctor or pharmacist if you are not sure.
• The dosage depends on the indication and the magnesium serum mirror.
  • The recommended dosage is
    • For pre -declampsia, eclampsia: 4 - 6 g magnesium sulfate (16 - 24 mmol magnesium) i.v. In diluted form using a perfusor or short infusion over 15 - 20 minutes.
    • Conservation dose 1 - 2 g magnesium sulfate / hour (4 - 8 mmol magnesium / hour) up to 24 - 48 hours post partum.
    • In early birthdays, as an additional therapy for tokolysis with betamimetics: 4 - 8 mmol magnesium / hour.
    • With heavy magnesium deficiency: 20 mmol magnesium / day.

       

• If you have used a larger amount than you should:
  • The main symptoms and general signs of overdose are muscle weakness, disappear the deep tendon reflexes, waste of blood pressure and the heart rate, increase in skin blood circulation, ECG changes, vomiting, sedation and confusion.
  • If the plasma magnesium concentration exceeds 2 mmol/l, the deep tendon reflexes are weakened, at approx. 5 mmol/l they are no longer available and breathing appression occurs. At 6.0 - 7.5 mmol/l there is a coma and from 8 mmol/l, breathing paralysis and diastolic cardiac arrest.
  • Magnesium intoxication is to be treated with intravenous calcium intake-as an antidot-(e.g. slow IV administration of 10 ml of a 10%calcium gluconate solution). In addition, the cholinesterase blocker should be administered neostigmin because it increases the acetylcholine concentration and the muscle-relaxing effect of magnesium is antagonized.

• If you have forgotten the application
  • Do not apply twice the amount if you have forgotten the previous application.

Taking

• The infusion solution concentrate should be diluted and then intravenously infused.
• As dilution solutions, z. For example: 5%glucose and 0.9%sodium chloride solution.
• As an additional therapy for tocolysis with betamimetics, 0.9%sodium chloride solution should be used as a dilution solution instead of the hyperglycemic effect of the tokolytics instead of the 5%glucose solution.
• The ready -to -use infusion solution is to be applied immediately after dilution.
• Parenteral magnesium sulfat evidence should-due to possible treasures-generally not mix with calcium, phosphate, tetracycline-containing or alcoholic solutions.
• In premature birthsn, as an additional therapy for tokolysis with betamimetics:
  • For the production of the infusion solution z. B. 2 Mix the ampoules with 480 ml of dilution solution.
• With severe magnesium deficiency:
  • For the production of the infusion solution z. B. 1 ampoule with 990 ml of dilution solution.
• The dosage depends on the application area or the magnesium serum mirror.

Patient information

• Warnings and Precautions
  • Please speak to your doctor or pharmacist before using the preparation.
  • Special care in the application is required,
    • In the event of severe excretion disorders of the kidneys. A dose adjustment to the degree of the excretion disorder is necessary.
    • The following surveillance and precautionary measures are to be taken during high-dose parenteral magnesium therapy:
      • Control of the cardiovascular and breathing function (breathing frequency not under 16/min),
      • Examination of the triggerability of the patellar tendon reflexes,
      • Determination of urine output (not below 25 ml/h),
      • Realance of ampoules of calcium gluconate, 10%as an antidot
      • Warranty intensive care measures if the anti -dot alone is not sufficient.
  • The medicine should not be mixed with calcium, phosphate, tetracycline-containing or alcoholic solutions due to possible treasures.
  • Children and adolescents
    • No data is available.

• Wateriness and ability to use machines:
  • No special precautions are required for intended use.

Pregnancy

• There is no evidence of a malformation risk. However, the documented experiences in humans with the application in early pregnancy are very low. The drug should therefore only be applied by the attending doctor after the risk of benefits.
• If magnesium is administered parenterally shortly before birth, the newborn should be monitored during the first 24 - 48 hours of life to signs of toxicity (neurological depression with breathing depression, muscle weakness, loss of reflexes). The administration of aminoglycoside antibiotics should be avoided during this period, since there are indications of interactions.
• With parenteral use of magnesium to inhibition of labor over a longer period of time in high doses, there have been reports on disorders of the skeletal annoying in newborns. However, there are no concerns when applying in the indicated therapeutic dosage.

Hints

Miscellaneous

The following surveillance and precautionary measures are to be taken during the high-dose intravenous magnesium therapy:
- Control of the cardiovascular and breathing function (breathing rate not under 16/min)
- Examination of the triggerability of the patellar tendon reflexes
- Determination of urine output (not below 25 ml/h)
- Stewing ampoules of calcium gluconate, 10%as an antidot (antidote)
- Warranty intensive care measures if the anti -dot alone is not sufficient.