PASCORBIN Injection solution ampoules, 100x5 ml

Instructions for use for PASCORBIN Injection solution ampoules, 100x5 ml

Application notes

Application areas

Mode of action

How does the ingredient of the medicine work?

The active ingredient is water -soluble vitamin C. It supports the immune system in the fight against pests and, together with vitamin e, makes aggressive oxygen compounds and so -called free radicals harmless. Less serious illnesses such as a cold or a flu infection are positively influenced. In addition, he accelerates blood clotting, keeps some toxic heavy metals at bay and enables the organism to absorb more iron from the intestine. In addition, the active ingredient can act as a buffer and thus contributes to the fact that a medicine becomes more stomach.

Composition

Contradictions

What speaks against an application?

Always:
- Hypersensitivity to the ingredients
- Kidney stones made of calcium oxalate
- Iron storage disease, such as:
- Genetically related disorder of hemoglobin formation (thalassemia)
- Iron storage disease with organ damage (hemochromatosis)
- Anemia with disturbed iron recycling (sideroblastic anemia)

Under certain circumstances - speak to your doctor or pharmacist:
- Impaired kidney function
- Dialysis (hemodialysis)
- Glucose-6-phosphate dehydrogenase deficiency (special inherited metabolic disease)
- Signs of respiratory disease (respiratory symptom)

Which age group must be observed?
- Adults: In this age group, the drug should only be used for certain areas of application. Please ask your doctor or pharmacist, if you have questions regarding this topic.

What about pregnancy and lactation?
- Pregnancy: Contact your doctor. Various considerations play a role in whether and how the medicine can be used during pregnancy.
- Still -time: Contact your doctor or pharmacist. He will check your special starting position and advise you accordingly whether and how you can continue with breastfeeding.

Is the medicine despite a Gegen indicator has been prescribed, speak to your doctor or pharmacist. The therapeutic benefit can be higher than the risk of using the application.

Side effects

What adverse effects may occur?

- Allergic hypersensitivity of the respiratory tract
- Skin reaction
- Circulatory disorder, e.g.
- Dizziness
- Nausea
- Vision of vision
- Schüttelfrost, with acute infections
- Increased body temperature, with current infections

If you notice a disorder or change during treatment, contact your doctor or pharmacist.

For information at this point, side effects are taken into account that occurs in at least one of 1,000 patients treated.

Hints

What should you consider?
- Beware of allergy to ascorbic acid (vitamin C)!
- There can be medicinal products with which interactions occur. Therefore, you should generally provide the doctor or pharmacist before treatment with a new medicine. This also applies to medicines that you buy yourself, only apply occasionally or that the application has been available for some time.

Detailed instructions for PASCORBIN Injection solution ampoules, 100x5 ml

Field of use

• Ascorbic acid (vitamin C) is a water -soluble vitamin.
• The medicine is used
  • for the therapy of clinical vitamin C deficiency states that cannot be remedied or orally substituted in diet.
  • Methemoglobinemia in childhood.

Active ingredients / ingredients / ingredients

750 mg ascorbic acid
Sodium hydrogen carbonate auxiliary material (+)
Water, for injection purposes auxiliary material (+)

Contradictions

• The medicine must not be used at:
  • In the following it is described when this medicine may only be used under certain conditions and only with special caution. Please ask your doctor. This also applies if this information has been on your own.
  • The preparation may only be used after consultation with your doctor in kidney stones from oxalate and certain diseases in which too much iron is stored in the body (thalassemia, hemochromatosis, sideroblastic anemia).

dosage

• Always apply the medicine exactly according to the instruction. Please ask your doctor or pharmacist if you are not quite sure.
• The medicine is generally used by a doctor.
• Unless otherwise prescribed by the doctor, the usual dose is:
  • Unless otherwise prescribed, 5 ml slowly injecting 5 ml daily, up to 50 ml injection solution as an addition to the infusion.
  • In order to prevent a vitamin C deficiency in the case of longer artificial (parenteral) nutrition, adults receive 100 to 500 mg of ascorbic acid per day (corresponding to 0.7 ml to 3.3 ml).
  • Children intravenously 5 to 7 mg ascorbic acid/kg kg per day.
  • Methemoglobinemia in childhood:
    • 500 To 1000 mg of ascorbic acid (corresponding to 3.3 ml to 6.6 ml) are intravenously injected.
    • If necessary, the gift must be repeated with the same dosage.
    • A dose of 100 mg/kg kg per day should not be exceeded.

 

• Duration of the application
  • Your doctor decides on the duration of the application due to the course of the disease and the blood values.

 

• If you have used a larger amount than you should
  • The application is interrupted. Other measures are generally not necessary, except for hemolysen or kidney stones.
  • In the event of pain in the kidney area or difficult urination after a high dose, a doctor must be informed immediately.

Taking

• The medicine is slowly injected by your doctor or other medical staff (into the veins).

Patient information

• Warnings and Precautions:
  • Injection of high doses can lead to acute kidney failure due to kidney stones by precipitation calcium oxalate crystals in the kidney. This has already been observed in doses of 1.5 - 2.5 g. Patients with an existing restriction of kidney function (renal failure) are particularly at risk for this.
  • Adequate fluid intake (approx. 1½ to 2 l per day) should be taken into account.
  • In patients with recurring kidney stone formation, the daily vitamin C dose should not exceed 100 to 200 mg. Patients with high -grade or terminal renal failure (dialysis patients) should not receive more than 50 to 100 mg every day.
  • In patients with erythrocytic glucose-6-phosphate dehydrogenase deficiency (hereditary disturbance of the metabolism of the red blood cells), with high doses of vitamin C (more than 4 g daily), e.g. T. heavy hemolysen (resolution of red blood cells) observed. Exceeding the dosage of 100 - 500 mg ascorbic acid daily must therefore be avoided.
  • In patients with known breathing difficulties (especially by restricting breathing function, such as asthma, chronic bronchitis or smoking cough), treatment with high doses (from 7.5 g) can occur in individual cases. It is therefore recommended to start treatment with lower doses in these patients.
  • This preparation must not be mixed with drugs, the effect of which is reduced by chemical reduction.
  • Children
    • In children under the age of 12, an IV - 7 mg ascorbic acid/kg kg per day should not be exceeded in children under the age of 12.
    • As part of the therapy of methemoglobinemia in childhood, a lot of 100 mg ascorbic acid/kg kg should not be exceeded every day.
  • Older people
    • Adequate fluid intake (approx. 1½ to 2 l per day) should be taken into account.
  • Special note for diabetics
    • After parenteral administration of ascorbic acid, the detection reaction of glucose is disturbed in the blood.
  • Hints
    • According to the gift of grammar, the ascorbic acid concentration in the urine can rise to such a way that the measurement of various clinical-chemical parameters (glucose, uric acid, creatinine, inorganic phosphate) is disturbed and falsified.

 

• Wateriness and operating machines
  • There are no special precautions required.

Pregnancy

• Pregnancy
  • In pregnancy, a lot of 100 to 500 mg of ascorbic acid should not be exceeded every day.
• Breastfeeding
  • During breastfeeding, a lot of 100 to 500 mg ascorbic acid should not be exceeded every day.

Hints

Miscellaneous

- In patients with already restricted kidney function, the precipitation of calcium oxalate crystals in the kidney can lead to acute kidney failure.

- In patients with recurring kidney stone formation, the daily vitamin C dose should not exceed 100 to 200 mg. Patients with high -grade or terminal renal failure (dialysis patients) should not receive more than 50 to 100 mg every day.

- In patients with erythrocytic glucose-6-phosphate dehydrogenase deficiency (hereditary disturbance of the metabolism of the red blood cells), with high doses of vitamin C (more than 4 g daily), e.g. T. heavy hemolysen (resolution of red blood cells) observed. Exceeding the dosage of 100 - 500 mg ascorbic acid daily must therefore be avoided.

- The preparation must not be mixed with medicinal products, the effect of which is reduced by chemical reduction.

- An ampoule with a 5 ml injection solution contains 4.2 mmol (97.2 mg) sodium and an injection bottle with 50 ml injection solution contains 42.3 mmol (972 mg) sodium. This should be taken into account in patients who have to comply with a salt stance.

- Note for diabetics: After intravenous administration of ascorbic acid, the detection reaction of glucose is disturbed in the blood.

Manufacturer:  Pascoe Pharmaceutical preparations, Schiffenberger Weg 55, 35394 Gießen